Research biomodels

We offer you biomodels from the Charles River company, whose exclusive distributor we are. More information about the strains offered can be found at www.criver.com. For information on prices and availability of strains do not hesitate to contact us at info@velaz.cz.

 

  • Mice

    This is description of category Mice. It may also contain media.

     


    • Outbred
      NMRI

      Origin

      Swiss-type mouse, which Clara Lynch gave to Poiley in 1937. He maintained an inbred line of this animal until the 51st generation, before he transferred it to the Naval Medical Research Institute. Introduced into Charles River Laboratories in 1979 from the Central Institute for Laboratory Animal Breeding - Hannover (Germany).

      Coat color

      White (Albino)

      Research application

      Model for general use, including toxicology, teratology, pharmacology (especially in psychopharmacology for behavioral studies) and physiology

      Breeding location

      Germany, France


      CD - 1 IGS

      Origin

      The original group of Swiss mice that served as progenitors of this stock consisted of two male and seven female albino mice derived from a non-inbred stock in the laboratory of Dr. de Coulon, Centre Anticancereux Romand, Lausanne, Switzerland. These animals were imported into the United States by Dr. Clara Lynch of the Rockefeller Institute in 1926. The Hauschka Ha/ICR stock was initiated in 1948 at the Institute for Cancer Research (ICR) in Philadelphia from “Swiss” mice of Rockefeller origin. To Dr. Edward Mirand of Roswell Park Memorial Institute where they were designated as HaM/ICR. To Charles River in 1959.

      Strain code

      022

      Coat color

      White (albino); carries black agouti behind its albino gene

      Research application

      General multipurpose model, safety and efficacy testing, aging, surgical model, pseudopregnancy


    • Inbred

      BL/6N

      Origin

      Developed by C.C. Little in 1921, from a mating of Miss Abby Lathrop’s stock that also gave rise to strains C57BR and C57L. Strains 6 and 10 separated about 1937. To The Jackson Laboratory in 1948 from Hall. To NIH in 1951 from The Jackson Laboratory at F32. To Charles River in 1974 from NIH.

      Strain code

      027

      Coat color

      Black

      Research application

      General multipurpose model, diet-induced obesity, transgenic/knockout model development, safety and efficacy testing, immunology

      MHC Haplotype

      H2b


      Balb/cN

      Origin

      H.J. Bagg developed the “Bagg albino” in 1913 from stock from an Ohio pet dealer. Inbred in 1923 by McDowell. To Snell in 1932 at F26, then to Andervont in 1935. To NIH in 1951 from Andervont at F72. To Charles River in 1974 from NIH.

      Strain code

      028

      Coat color

      White (Albino)

      Research application

      General multipurpose model, hybridoma development, monoclonal antibody production, infectious disease

      MHC Haplotype

      H2d


    • Immunodeficient

      SCID mouse models

      SCID mice possess a genetic autosomal recessive mutation designated Prkdcscid.** They are homozygous for the Prkdcscid allele, which has been mapped to the centromeric end of chromosome 16. These mice have severe combined immunodeficiency affecting both B and T lymphocytes.

      They lack functional lymphocytes because of impaired VDJ rearrangement (rearrangement of separate gene elements of the immunoglobulin and T-cell antigen receptor genes). While typical SCID mice are haired, our portfolio includes hairless models that make ideal candidates for tumor imaging and measurements:

      NOD SCID

      The SCID mutation has been transferred onto a non-obese diabetic background. Animals homozygous for the SCID mutation have impaired T and B cell lymphocyte development. The NOD background additionally results in deficient natural killer (NK) cell function. To Charles River in 2003 from NIH.

      Coat Color: White (albino)

      Ideal For: Tumor biology and xenograft research

      NSG® mice

      Developed by Dr. Lenny Shultz at The Jackson Laboratory, the JAX® Mice strain NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (005557) is commonly known as the NOD scid gamma (NSG®). It is a mutant mouse which combines the features of the NOD/ShiLtJ background (conferring a number of deficiencies in innate immunity), the severe combined immune deficiency mutation (scid) and an IL2 receptor gamma chain deficiency which disables cytokine signalling. As a result, the NSG® mice lack mature T cells, B cells, functional NK cells, and are also deficient in cytokine signaling.

      Coat Color: White (albino)

      Ideal For: Oncology, immunology, virology research, xenograft/transplant host (outstanding utility in the studies of islet transplantation, hematopoietic stem cells and cancer stem cells)


      Athymic Nude Mice

      This immunodeficient nude mouse originated from NIH and was originally thought to be a BALB/c congenic. It was later determined that it was not inbred and is therefore maintained as an outbred. It is not associated with any stock or strain. The animal lacks a thymus, is unable to produce T cells, and is therefore immunodeficient. To Charles River from NCI in 2010.

      Coat color: Hairless, albino background

      Ideal for:  Tumor biology and xenograft research


    • JAX

  • Rats

    • Outbred

      Wistar

      Origin

      To Scientific Products Farm, Ltd. [predecessor of Charles River United Kingdom (CRUK)] in 1947 from Wistar Institute. To Charles River in 1975 from CRUK. This particular colony was selected because of a low incidence of hydronephrosis.

      Strain code

      003

      Coat color

      White (albino)

      Research application

      General multipurpose model, infectious disease research, safety and efficacy testing, aging

      Breeding lacation

      US, Germany, UK, Canada


      CD®(Sprague Dawley)

      Classic multipurpose model

      Origin

      Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. To Charles River in 1950 from Sprague Dawley, Inc. In 1991, 8 colonies were selected to form the IGS Foundation Colony. Rederived into an isolator foundation colony in 1997. IGS refers to animals bred using the Charles River International Genetic Standardization system.

      Strain code

      001

      Coat color

      White (Albino)

      Research application

      General multipurpose model, safety and efficacy testing, aging, nutrition, diet-induced obesity, oncology

      Breeding location

      US, Germany, UK, Italy, Canada


    • Inbred

      Lewis

      Origin

      Developed by Dr. Lewis from Wistar stock in the early 1950s. To Charles River from Tulane in 1970 at F34.

      Strain code

      004

      Coat color

      White (albín)

      Research application

      Transplantation research, induced arthritis/inflammation, experimental allergic encephalitis, STZ-induced diabetes

      MHC Haplotype

      RT1l

      Breeding location

      US, Germany, UK


      Brown Norway

      Origin

      Silvers and Billingham began brother x sister matings with selection for histocompatibility in 1958 from a brown mutation in a stock of wild rats maintained by King and Aptekman in a pen-bred colony of rats trapped from the wild in 1930 by King at the Wistar Institute. To Charles River from Radiobiology Institute, Netherlands in 1976.

      Strain code

      091

      Coat color

      Non-agouti brown

      Research application

      Genetic mapping, respiratory inflammation, immunological dysfunction, aging, transplantation research

      MHC Haplotype

      RT1n

      Breeding location:

      US, Germany, UK


  • Other species

    Dunkin-Hartley guinea pig

    Origin

    To Charles River in 1968 from Medical Research Council, Millhill, England.

    Strain code

    051

    Coat color

    White (acromelanic albino)


    New Zealand White rabbit (NZW)

    Origin

    The NZW rabbit was obtained in 1991 by Charles River Canada (CRC) from Kitayama Labs K.K. of Nagano Prefecture, Japan.

    Strain code

    052

    Coat color

    White (albino)