NOTE: The E indicates that this animal’s health status meets our VAF/Elite™ profile. For additional information, please check out the VAF/Elite™ definition: http://www.criver.com/files/pdfs/rms/rm_rm_r_vaf_profiles.aspx
Developed by Dr. L.C. Stevens from The Jackson Laboratory. During the 1970s, Dr. Stevens introduced this line to ... more
The 11BHSD2 mouse was produced by injection of a construct, containing 11β-HSD2 cDNA isolated from mouse kidney and cloned into plasmid Clone 26 to recruit the 5.4 kb mouse α–myosin heavy chain (α-MHC) promoter, into pronuclei of C57BL/6 embryos. ... more
Mice bred in The Jackson Laboratory may be ordered on demand. Please, contact us at email@example.com.
That includes these strains:
NOD ... more
Swiss-type mouse, which Clara Lynch gave to Poiley in 1937. He maintained an inbred line of this animal until the 51st generation, before he transferred it to the Naval Medical Research Institute. Introduced into Charles River Laboratories in 1979 ... more
Athymic Nude Mice
This immunodeficient nude mouse originated from NIH and was originally thought to be a BALB/c congenic. It was later determined that it was not inbred and is therefore maintained as an outbred. It is not associated with any stock or ... more
The hairless SCID congenic was created in 2009 by Charles River Research Models by using marker-assisted accelerated backcrossing to place the hairless gene (Hrhr) present in the Crl:SKH1-Hrhr stock onto a CB17/Icr-Prkdcscid/IcrIcoCr genetic background. These mice are homozygous for both Hrhr and Prkdcscid mutations, ... more
This immunodeficient nude mouse originated from NIH and was originally thought to be a BALB/c congenic. It was later determined that it was not inbred and is, therefore, maintained as an outbred and is not associated with any stock ... more
Most commonly called the NIH-III, it was developed at NIH. In addition to the nude gene, which results in the absence of thymus and T-cell function, this mouse has two other mutations important in regulating the function of the ... more
SCID Beige mice
A congenic mouse that possesses both autosomal recessive mutations SCID (Prkdcscid) and beige (Lystbg-J). The SCID mutation results in severe combined immunodeficiency affecting both the B and T lymphocytes. The beige mutation results in defective natural killer (NK) cells. ... more
The hairless SCID mouse was produced by Charles River Research Models in 2007 by inter-crossing the Crl:HA-Prkdcscid and Crl:SKH1-Hrhr stocks. The resulting animals are homozyogous for the Prkdcscid and theHrhr mutations and thus exhibit the severe combined immunodeficiency phenotype characteristic of SCID mice and ... more
SCID mice possess a genetic autosomal recessive mutation (SCID). Discovered in 1980 by Bosma in C.B-17/Icr mice at Fox Chase Cancer Center. SCID mice show a severe combined immunodeficiency affecting both B and T lymphocytes. They have normal NK ... more
Developed through crosses and back-crosses between BALB/cABom-nu and BALB/cAnNCrj at Charles River Laboratories Japan (CRLJ). Pedigreed pregnant females of CAnN.Cg-Foxn1nu/Crl were received from CRLJ in 1985. This mouse is inbred, and genetic monitoring results confirm it to be a BALB/c ... more
The mutation occured in 1962, in a colony of albino outbred mice maintained at the Ruchill Hospital in Glasgow. In 1966, Flanagan gave the first detailed description of this mutant. It was not until 1986, however, that it was ... more
In 1995, a subpopulation of CF-1™ mice with deficient expression of mdr1a P-glycoprotein (PGP) was identified by the department of Safety Assessment, Merck Research Laboratories, West Point, PA. Genotyping led to the identification of homozygous populations, mutant (-/-) and wild-type (+/+), ... more
From the Walter and Eliza Hall Institute, Victoria, Australia, to Charles River France in 2002. These homozygous transgenic mice express the mouse alpha-chain and beta-chain T cell receptor that pairs witht the CD4 coreceptor and is specific for chicken ... more
From the Walter and Eliza Hall Institute, Victoria, Australia, to Charles River France in 2002.
These homozygous mice contain transgenic inserts for mouse Tcra-V2 and Tcrb-V5 genes. The transgenic T cell receptor was designed to recognize ovalbumin residues 257-264 in ... more
The strain was originally developed at the Sloan Kettering Institute where it was backcrossed on a non-specified C57BL/6 strain. The congenic strain C57BL/6-Ly5.1 carries the allele of the SJL mouse in the Ptprc gene locus: Ptprca or CD45.1 or Ly5.1. Charles ... more
The Pound Mouse
This model was isolated from a C57BL/6NCrl colony in a Charles River Laboratories barrier facility in the United States in 2005. The mutation was mapped to a region within less than 2 cM of the leptin receptor on Chr ... more
The hybrid NMRCF1/Crl mouse is a result from a cross between a Crl:NMRI female and a JAXTM Mice Strain BALB/cByJ male.
Coat ... more
First generation (F1) progeny of a cross between female BALB/cAnNCrl and male DBA/2NCrl mice.
Breeding ... more
A cross between female BALB/c and male C57BL/6.
Transplantation research, monoclonal antibody ... more
A cross between female C57BL/6 and male C3H. Contact us for further information.
Safety and efficacy testing, transgenic/knockout model development, transplantation ... more
Received by NCI from Dr. Allan Bradley at Baylor College of Medicine in 2000. The B6 albino strain is a spontaneous albino mutant coisogenic C57BL/6 strain. The mice contain a mutation in the tyrosinase gene, and when homozygous for ... more
Derived in 1935 from an outbred Swiss colony [N:GP(S)] at NIH. In the early 1970s, while being established as an inbred strain, sensitivity to Friend leukemia virus B strain was discovered. At this time inbreeding of this line for the Fv1b allele ... more
Developed by C.C. Little in 1909 from stock segregating for coat color. Oldest of all the inbred strains of mice. In 1929-1930, crosses were made between sublines, and several new sublines were established, including the widely used sublines 1 ... more
From a cross of a Bagg albino female and a DBA male by Strong in 1920. The CBA strain was selected for a low mammary tumour incidence. Transferred via The Jackson Laboratory to Haldane and Gruneberg in 1932. To Carter ... more
Developed by C.C. Little in 1921, from a mating of Miss Abby Lathrop’s stock that also gave rise to strains C57BR and C57L. Strains 6 and 10 separated about 1937. To The Jackson Laboratory in 1948 from Hall. To ... more
From a cross of a Bagg albino female and a DBA male by Strong in 1920. A litter of 4 females and 2 males sent to Andervont in 1930, then to Heston at F35. To NIH in 1951 from ... more
H.J. Bagg developed the “Bagg albino” in 1913 from stock from an Ohio pet dealer. Inbred in 1923 by McDowell. To Snell in 1932 at F26, then to Andervont in 1935. To NIH in 1951 from Andervont at F72. ... more
Developed by Dr. L.C. Stevens from The Jackson Laboratory. During the 1970s, Dr. Stevens introduced this line to the Pasteur Institute of Paris in the laboratory of Dr. J.L. Guenet. To Iffa Credo in August 1996. To Charles River ... more
Developed at the NIH Genetic Resource by Dr. Carl Hansen. N:NIH Swiss outbred mice (albino) were crossed to C57BL/6N (black, non-agouti) mice to generate a hybrid black mouse that was heterozygous for the agouti locus. Through a series of ... more
An uncharacterized non-pedigreed hairless strain of mice was acquired
by Temple University from a small commercial supplier in New York City.
To Charles River from the Skin and Cancer Hospital at Temple University
in 1986. This mouse is euthymic and immunocompetent.
No ... more
In 1935, Carworth Farm began to breed a line of mice for vigor and
productivity. Progenitors originating from a colony bred in Missouri were
bought and the strain was named CF1 (Carworth Farm 1). This strain
was introduced to Charles River ... more
These albino mice, which were originally developed at Olac prior to 1970, came from a cross between the Laboratory Animal Centre A-strain mice (‘LACA’ - but formerly called CFW) and the CS1 from Scientific Products Farm (acquired by Charles ... more
CD – 1 IGS
The original group of Swiss mice that served as progenitors of this stock consisted of two male and seven female albino mice derived from a non-inbred stock in the laboratory of Dr. de Coulon, Centre Anticancereux Romand, Lausanne, Switzerland. ... more
HSD11B1 mice were created by Pfizer, Inc. Transferred to Charles River under exclusive license in 2011.
519 HE, 520 HO, 521 WT
For further information or to place an order, please contact us at firstname.lastname@example.org ... more