Rats

Long Evans

Origin Originated by Drs. Long and Evans in 1915 by crossing several Wistar Institute white females with a wild gray male. To Charles River from Canadian Breeding Farm and Laboratories in 1978. Strain Code 006 Coat color White with black hood; occasionally white with ... more

RNU (Nude rat)

Origin The NIH nude rat was developed in 1979–1980 through a series of matings involving 8 inbred rat strains. To Charles River from the National Institutes of Health in 2001. This athymic nude rat is T-cell deficient and shows depleted ... more

SHRSP

Origin The SHRSP was isolated from Wistar-Kyoto rats by Okamoto and Aoki in 1963. The A3 subline was transferred to the National Institutes of Health in 1975 from Yamori at generation F36. To Charles River in 2002. Strain code 324 Coat color White (albino) Research ... more

OPRL1

Origin This strain was created in the laboratory of Dr. Edwin Cuppen at the Hubrecht Institute in the Netherlands. Biochemical characterization revealed that the OPRL1 functional protein (Nociceptin Receptor) is completely absent in homozygous knock-out rats and that there is ... more

SERT

Origin This strain was created in the laboratory of Dr. Edwin Cuppen at the Hubrecht laboratory in the Netherlands. Biochemical characterization revealed that SERT mRNA and functional protein are completely absent in homozygous knock-out rats and that there is a ... more

BDIX

Origin Druckrey from a cross between BDI and BDVIII with subsequent selection of brother-sister pairs for agouti coat color and dark, pigmented eyes. To Charles River in 1998 from the National Cancer Institute Animal Production Program (Cr). Strain code 284 Coat color Agouti Research application Leukemia ... more

Buffalo

Origin Heston in 1946 from Buffalo stock of H. Morris. To NIH in 1951 at F10. To Charles River in 1998 from the National Cancer Institute Animal Production Program (Cr). Strain code 281 Coat color White (albino) Research application Carcinogenesis, oncology MHC Haplotype RT1b Breeding ... more

Noble

Origin Bogden in the mid-1970s from Noble strain rats (brother x sister mated but not descended from a single pair, and therefore not necessarily isogenic). To National Cancer Institute Animal Production Program (Cr) in 1978. To Charles River in 1998. Strain ... more

Wistar Furth

Origin J. Furth in 1945 from a commercial Wistar stock in an attempt to develop a rat strain with a high incidence of leukemia. To Charles River in 1998 from the National Cancer Institute Animal Production Program (Cr). Coat color White (albino) Research ... more

p53 TGEM Knockout

Origin At the Hubrecht Institute a nonsense mutation at amino acid position 273 (Cys to stop) within the DNA binding domain of the rat p53 gene was isolated, which resulted in a full knockout mutation. Systematic generation of the p53 ... more

RIP-HAT

Origin The RIPHAT transgene consists of a PCR-generated cDNA encompassing the h-IAPP coding sequence under the regulation of the rat insulin II promoter/5’untranslated region and followed by intron I from the human albumin gene and the polyadenylation site/RNA termination region ... more

GK

Origin The Goto-Kakizaki (GK) rat is a non-obese Wistar substrain which develops Type 2 diabetes mellitus early in life. The model was developed by Goto and Kakizaki at Tohoku University, Sendai, Japan in 1975. To Chugai Pharmaceutical Co. To Charles ... more

SHHF

Origin Breeding stock for this colony was transferred to Dr. Sylvia McCune at the University of Chicago Medical School in 1983 from the laboratory of J.E. Miller at G.D. Searle and Company. The animals were developed by backcrossing the SHROB ... more

ZSF1

Origin This hybrid rat is a cross between a ZDF female and an SHHF male rat. This model was developed at Genetic Models, Inc. in Indianapolis, IN. To Charles River in 2001. Strain code 378 (OBESE), 379 (LEAN +/?) Coat color Black hooded with ... more

PCK

Origin This model of polycystic kidney disease showing both kidney and liver involvement was identified in a colony of CD rats from the Charles River Japan production facility. The identification of the Pkhd1 gene mutation was reported by Katsuyama and ... more

BCRP Knockout

Origin At the Hubrecht Institute a nonsense mutation at amino acid position 59 (Glu to stop) within the catalytic center ABC transporter-like domain of the rat Abcg2 (Bcrp) gene was isolated which eliminates all wild-type protein. Transferred to Charles River ... more

Zucker

Origin The obese or fatty condition appeared spontaneously in the 13M strain maintained at the Laboratory of Comparative Pathology of Theodore and Lois Zucker in Stow, MA. Research colonies were established at many institutions from this nucleus colony. To Charles ... more

ZDF

Origin A mutation occurred in a colony of outbred Zucker rats in the laboratory of Dr. Walter Shaw at Eli Lilly Research Laboratories in Indianapolis, IN in 1974–75. Part of this colony containing the mutation was moved to Indiana University ... more

Wistar Kyoto

Origin Outbred Wistar stock from Kyoto School of Medicine to NIH 1971. This is the same stock from which the SHR/N strain was developed. To Charles River in 1974 from NIH at F11. Coat color White (albino) Strain code 008 Research application Control for the SHR ... more

CD Hairless

Origin This spontaneous mutation model was isolated from a Crl:CD(SD) colony in Charles River, in the late 1980s. Rederived in 1993 and subsequently transferred to Charles River, Raleigh, NC for barrier room production. The model does not exhibit the typical ... more

SHR

Origin Okamoto, Kyoto School of Medicine, 1963, from outbred Wistar Kyoto male with marked elevation of blood pressure mated to female with slightly elevated blood pressure. Brother x sister mating with continued selection for spontaneous hypertension was then started. To ... more

Wistar WU

Strain origin Selection by H.H. Donalson at the Wistar Instiute, USA, at the begining of 19th century. To Glaxo-Lab. In 1927, continued as inbred. To Nederlands-Instituut voor Volksfoending in 1933, to Unilever, Vlaardingen in 1941 and Institut Centraale Proefdierenbedrijf TNO in 1958. Hysterectomy rederived ... more

WAG

Origin Inbred by A.L. Bacharach, Glaxo Labs., U.K., 1924, from a Wistar stock. To Harrington in 1964 at F83. To MBL-TNO in 1953, after that to REP Institutes TNO, Rijswijk. To Charles River Germany from REP Institutes TNO in 1993 Coat color White ... more

Wistar

Origin To Scientific Products Farm, Ltd. [predecessor of Charles River United Kingdom (CRUK)] in 1947 from Wistar Institute. To Charles River in 1975 from CRUK. This particular colony was selected because of a low incidence of hydronephrosis. Strain code 003 Coat color White (albino) Research ... more

Lewis

Origin Developed by Dr. Lewis from Wistar stock in the early 1950s. To Charles River from Tulane in 1970 at F34. Strain code 004 Coat color White (albín) Research application Transplantation research, induced arthritis/inflammation, experimental allergic encephalitis, STZ-induced diabetes MHC Haplotype RT1l Breeding location US, Germany, ... more

Wistar Han IGS

Origin Rederived by GlaxoWellcome from Han Wistar stock supplied by BRL. Transferred to Charles River UK in 1996. Transferred to Charles River in 1997 and rederived into isolator maintained Foundation Colony. IGS refers to animals bred using the Charles River ... more

Fischer 344

Origin From mating #344 of rats purchased from a local breeder (Fischer). Colony originated by M.R. Curtis, Columbia University Institute for Cancer Research in 1920. Dunning at Columbia inbred to form the strain starting in 1920. Dunning to Charles River ... more

Brown Norway

Origin Silvers and Billingham began brother x sister matings with selection for histocompatibility in 1958 from a brown mutation in a stock of wild rats maintained by King and Aptekman in a pen-bred colony of rats trapped from the wild ... more

OFA

Origin The original strain was composed in 1925 by Robert Worthington Dawley. Carworth Farms obtained it in 1955 and renamed it CFE (Carworth Farms Elias).Transferred to Charles River France in 1967, it then became known as OFA (Oncins France Strain ... more

Lister Hooded

Origin The exact origin of the Lister Hooded rat is obscure, but it was certainly maintained at the Lister Institute in the 1920s. It is not thought to be closely related to the Long Evans rat. This stock was developed at the Lister ... more