In 1995, a subpopulation of CF-1™ mice with deficient expression of mdr1a P-glycoprotein (PGP) was identified by the department of Safety Assessment, Merck Research Laboratories, West Point, PA. Genotyping led to the identification of homozygous populations, mutant (-/-) and wild-type (+/+), ... more
From the Walter and Eliza Hall Institute, Victoria, Australia, to Charles River France in 2002. These homozygous transgenic mice express the mouse alpha-chain and beta-chain T cell receptor that pairs witht the CD4 coreceptor and is specific for chicken ... more
From the Walter and Eliza Hall Institute, Victoria, Australia, to Charles River France in 2002.
These homozygous mice contain transgenic inserts for mouse Tcra-V2 and Tcrb-V5 genes. The transgenic T cell receptor was designed to recognize ovalbumin residues 257-264 in ... more
The strain was originally developed at the Sloan Kettering Institute where it was backcrossed on a non-specified C57BL/6 strain. The congenic strain C57BL/6-Ly5.1 carries the allele of the SJL mouse in the Ptprc gene locus: Ptprca or CD45.1 or Ly5.1. Charles ... more
The Pound Mouse
This model was isolated from a C57BL/6NCrl colony in a Charles River Laboratories barrier facility in the United States in 2005. The mutation was mapped to a region within less than 2 cM of the leptin receptor on Chr ... more