Special models

PGP

Origin In 1995, a subpopulation of CF-1™ mice with deficient expression of mdr1a P-glycoprotein (PGP) was identified by the department of Safety Assessment, Merck Research Laboratories, West Point, PA. Genotyping led to the identification of homozygous populations, mutant (-/-) and wild-type (+/+), ... more

OT II

Origin From the Walter and Eliza Hall Institute, Victoria, Australia, to Charles River France in 2002. These homozygous transgenic mice express the mouse alpha-chain and beta-chain T cell receptor that pairs witht the CD4 coreceptor and is specific for chicken ... more

OT I

Origin From the Walter and Eliza Hall Institute, Victoria, Australia, to Charles River France in 2002. These homozygous mice contain transgenic inserts for mouse Tcra-V2 and Tcrb-V5 genes. The transgenic T cell receptor was designed to recognize ovalbumin residues 257-264 in ... more

Ly5.1

Origin The strain was originally developed at the Sloan Kettering Institute where it was backcrossed on a non-specified C57BL/6 strain. The congenic strain C57BL/6-Ly5.1 carries the allele of the SJL mouse in the Ptprc gene locus: Ptprca or CD45.1 or Ly5.1. Charles ... more

The Pound Mouse

Origin This model was isolated from a C57BL/6NCrl colony in a Charles River Laboratories barrier facility in the United States in 2005. The mutation was mapped to a region within less than 2 cM of the leptin receptor on Chr ... more