Immunodeficient

Athymic Nude Mice

Origin This immunodeficient nude mouse originated from NIH and was originally thought to be a BALB/c congenic. It was later determined that it was not inbred and is therefore maintained as an outbred. It is not associated with any stock or ... more

SHC Mice

Origin The hairless SCID congenic was created in 2009 by Charles River Research Models by using marker-assisted accelerated backcrossing to place the hairless gene (Hrhr) present in the Crl:SKH1-Hrhr stock onto a CB17/Icr-Prkdcscid/IcrIcoCr genetic background. These mice are homozygous for both Hrhr and Prkdcscid mutations, ... more

NU/NU Mouse

Origin This immunodeficient nude mouse originated from NIH and was originally thought to be a BALB/c congenic. It was later determined that it was not inbred and is, therefore, maintained as an outbred and is not associated with any stock ... more

NIH-III Mouse

Origin Most commonly called the NIH-III, it was developed at NIH. In addition to the nude gene, which results in the absence of thymus and T-cell function, this mouse has two other mutations important in regulating the function of the ... more

SCID Beige mice

Origin A congenic mouse that possesses both autosomal recessive mutations SCID (Prkdcscid) and beige (Lystbg-J). The SCID mutation results in severe combined immunodeficiency affecting both the B and T lymphocytes. The beige mutation results in defective natural killer (NK) cells. ... more

SHO mice

Origin The hairless SCID mouse was produced by Charles River Research Models in 2007 by inter-crossing the Crl:HA-Prkdcscid and Crl:SKH1-Hrhr stocks. The resulting animals are homozyogous for the Prkdcscid and theHrhr mutations and thus exhibit the severe combined immunodeficiency phenotype characteristic of SCID mice and ... more

SCID mice

Origin SCID mice possess a genetic autosomal recessive mutation (SCID). Discovered in 1980 by Bosma in C.B-17/Icr mice at Fox Chase Cancer Center. SCID mice show a severe combined immunodeficiency affecting both B and T lymphocytes. They have normal NK ... more

Balb/C-nude

Origin Developed through crosses and back-crosses between BALB/cABom-nu and BALB/cAnNCrj at Charles River Laboratories Japan (CRLJ). Pedigreed pregnant females of CAnN.Cg-Foxn1nu/Crl were received from CRLJ in 1985. This mouse is inbred, and genetic monitoring results confirm it to be a BALB/c ... more

Nude mice

Origin The mutation occured in 1962, in a colony of albino outbred mice maintained at the Ruchill Hospital in Glasgow. In 1966, Flanagan gave the first detailed description of this mutant. It was not until 1986, however, that it was ... more